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doi:10.1038/ejcn.2017.132 2 Sotgia S, Fois AG, Paliogiannis P, Carru C, Mangoni AA, Zinellu A

When the brain is exposed to a certain degree of oxidative stress, glial cells can cause neuronal damage, but also secrete a large amount of neuropeptides to protect both glial cells and neurons, and improve the brains defense against oxidative stress (Toledano et al., 2016), so the protection of glial cells can be considered directly related to nervous system protection

In Vivo Studies and Potential Therapies Several DS mouse models have been developed to study the neurobiological and cognitive impairment mechanisms implicated in T21 (Gupta, Dhanasekaran, and Gardiner 2016

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